Regulation of synaptic vesicle recycling

Across TCGA patient cohorts, RNA activity of the Regulation of synaptic vesicle recycling pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHE, CRTAM, and PLCL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic vesicle recycling activity versus SHE in LSCC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SHE →	+0.549	+0.238	<.001	<.001	3	6
BRCA	CRTAM →	+0.554	+0.127	.001	.004	3	5
GBM	PLCL1 →	+0.755	+0.127	<.001	<.001	3	5
HNSC	ZNF831 →	+0.551	+0.108	.003	.006	3	5
HNSC	ARHGEF6 →	+0.664	+0.135	<.001	.001	3	5
LSCC	TESPA1 →	+0.763	+0.279	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903421 vs SHE — LSCC

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