Regulation of synaptic vesicle recycling

Across TCGA cell cohorts, RNA activity of the Regulation of synaptic vesicle recycling pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUCLA2, FAAH2, and ADCK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SUCLA2 grouped by Regulation of synaptic vesicle recycling-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SUCLA2 →	+0.673	+0.308	.003	<.001	3	4
STOMACH	FAAH2 →	+2.047	+0.321	.001	.005	2	5
LUNG_SCLC	ADCK1 →	+0.438	+0.215	.001	<.001	3	4
PANCREAS	TUT1 →	-0.473	-0.209	.004	<.001	3	4
BLOOD_Leukemia	TMEM19 →	+1.241	+0.179	<.001	<.001	3	4
BLOOD_Leukemia	FMR1 →	+0.877	+0.178	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SUCLA2 by Regulation of synaptic vesicle recycling activity — STOMACH

Explore this box plot interactively →