Regulation of synaptic vesicle recycling

Across TCGA cell cohorts, RNA activity of the Regulation of synaptic vesicle recycling pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNAPC5, NPC2, and PYCR2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic vesicle recycling activity versus SNAPC5 in CNS (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SNAPC5 →	-0.922	-0.370	<.001	<.001	3	6
LIVER	NPC2 →	+2.052	+0.305	<.001	<.001	3	5
CNS	PYCR2 →	-0.454	-0.285	.003	.004	3	5
BLOOD_Myeloma	IFT52 →	+0.810	+0.186	<.001	<.001	3	4
BLOOD_Myeloma	BPGM →	+0.965	+0.143	.001	.005	3	4
URINARY_TRACT	AHSA1 →	-0.965	-0.360	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903421 vs SNAPC5 — CNS

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