Response to bile acid

Across TCGA patient cohorts, RNA activity of the Response to bile acid pathway is significantly associated with the RNA expression of multiple genes, with the KICH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VDR, ZNF491, and ZNF461, each associated with the pathway in up to 23 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to bile acid activity versus VDR in KICH (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	VDR →	+1.696	+0.165	<.001	<.001	3	23
THYM	ZNF491 →	-0.753	-0.045	<.001	.001	3	17
LAML	ZNF461 →	-0.515	-0.097	<.001	<.001	3	16
KICH	FAM228B →	-0.711	-0.189	<.001	<.001	3	16
LAML	ZNF709 →	-0.362	-0.116	<.001	<.001	3	16
THYM	GLCCI1 →	-0.939	-0.036	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903412 vs VDR — KICH

Explore this scatter interactively →