Response to bile acid

Across TCGA patient cohorts, RNA activity of the Response to bile acid pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIGLEC6, CPA3, and SIGLEC17P, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to bile acid activity versus SIGLEC6 in BRCA (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SIGLEC6 →	-0.765	-0.164	<.001	<.001	3	4
BRCA	CPA3 →	-2.302	-0.153	<.001	<.001	3	4
BRCA	SIGLEC17P →	-0.757	-0.177	<.001	<.001	3	4
BRCA	TPSB2 →	-2.562	-0.185	<.001	<.001	3	4
UCEC	SLC46A2 →	-0.535	-0.250	.005	.003	3	4
BRCA	MS4A2 →	-1.332	-0.163	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903412 vs SIGLEC6 — BRCA

Explore this scatter interactively →