Response to bile acid

Across TCGA cell cohorts, RNA activity of the Response to bile acid pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP7D3, SLC30A6, and CNTLN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP7D3 grouped by Response to bile acid-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MAP7D3 →	-1.475	-0.832	<.001	<.001	3	5
OVARY	SLC30A6 →	-0.449	-1.324	<.001	<.001	3	5
BREAST	CNTLN →	-1.191	-0.720	<.001	.001	3	5
BLOOD_Myeloma	CBX4 →	+1.870	+1.974	.007	.002	3	4
SOFT_TISSUE	SREBF1 →	+1.256	+0.972	.008	.006	2	5
OESOPHAGUS	RASSF4 →	-1.133	-1.080	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP7D3 by Response to bile acid activity — BREAST

Explore this box plot interactively →