Response to bile acid

Across TCGA cell cohorts, RNA activity of the Response to bile acid pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAGS, SP8, and TRIM62, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NAGS grouped by Response to bile acid-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NAGS →	+0.267	+0.149	<.001	<.001	3	4
PANCREAS	SP8 →	+0.265	+0.209	.001	<.001	3	4
BONE	TRIM62 →	-0.140	-0.109	.003	<.001	3	4
URINARY_TRACT	CKM →	+0.335	+0.158	.005	.004	3	4
BLOOD_Lymphoma	CD300A →	+0.276	+0.184	.002	<.001	3	4
LARGE_INTESTINE	CD40 →	-0.281	-0.237	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NAGS by Response to bile acid activity — STOMACH

Explore this box plot interactively →