Reactive oxygen species biosynthetic process

Across TCGA patient cohorts, RNA activity of the Reactive oxygen species biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIK3CG, TLR4, and IRAG2, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reactive oxygen species biosynthetic process activity versus PIK3CG in SCLC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	PIK3CG →	+1.205	+0.092	<.001	<.001	3	28
LAML	TLR4 →	+1.383	+0.049	<.001	<.001	3	27
SKCM	IRAG2 →	+0.867	+0.027	<.001	<.001	3	26
LAML	FGD2 →	+2.138	+0.060	<.001	<.001	3	26
LAML	LILRA1 →	+2.061	+0.055	<.001	<.001	3	25
DLBC	DOCK8 →	+1.175	+0.054	.009	.006	1	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903409 vs PIK3CG — SCLC

Explore this scatter interactively →