Reactive oxygen species biosynthetic process

Across TCGA patient cohorts, RNA activity of the Reactive oxygen species biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBP5, STX11, and BCL2A1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reactive oxygen species biosynthetic process activity versus GBP5 in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GBP5 →	+1.246	+0.188	<.001	<.001	3	8
LSCC	STX11 →	+0.631	+0.166	<.001	<.001	3	7
COAD	BCL2A1 →	+1.060	+0.176	.002	<.001	3	7
COAD	PIK3AP1 →	+0.816	+0.138	<.001	.001	3	7
LSCC	HK3 →	+0.813	+0.189	<.001	<.001	3	7
COAD	PELATON →	+0.598	+0.181	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903409 vs GBP5 — BRCA

Explore this scatter interactively →