Reactive oxygen species biosynthetic process

Across TCGA cell cohorts, RNA activity of the Reactive oxygen species biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB22A, SDCBP, and ZNF487, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB22A grouped by Reactive oxygen species biosynthetic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RAB22A →	+0.567	+0.748	.003	.008	3	4
KIDNEY	SDCBP →	+1.394	+1.031	<.001	.007	3	3
URINARY_TRACT	ZNF487 →	-1.070	-1.630	.002	.009	3	3
OVARY	VSIR →	-1.886	-1.202	.004	<.001	2	4
LUNG_NSCLC_LUAD	RREB1 →	+0.681	+0.433	<.001	.001	3	3
LUNG_NSCLC_LUAD	MATN3 →	-1.487	-0.364	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB22A by Reactive oxygen species biosynthetic process activity — LARGE_INTESTINE

Explore this box plot interactively →