Regulation of endoplasmic reticulum tubular network organization

Across TCGA patient cohorts, RNA activity of the Regulation of endoplasmic reticulum tubular network organization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LNPK, PRKRA_S18, and SPN_S368, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endoplasmic reticulum tubular network organization activity versus LNPK in OV (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LNPK →	+0.350	+0.058	<.001	<.001	3	7
LSCC	PRKRA_S18 →	+0.350	+0.059	.007	.001	3	5
GBM	SPN_S368 →	-0.375	-0.045	.005	.002	3	5
LUAD	ZC2HC1A_S223 →	+0.736	+0.046	<.001	<.001	3	5
PDAC	LARP4B_S736 →	-0.414	-0.048	<.001	<.001	3	5
COAD	RGS14 →	-0.846	-0.073	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903371 vs LNPK — OV

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