Regulation of endoplasmic reticulum tubular network organization

Across TCGA patient cohorts, RNA activity of the Regulation of endoplasmic reticulum tubular network organization pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C21orf62-AS1, ARHGAP27P1-BPTFP1-KPNA2P3, and TGFBR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endoplasmic reticulum tubular network organization activity versus C21orf62-AS1 in GBM (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	C21orf62-AS1 →	+0.445	+0.089	.006	.005	3	4
COAD	ARHGAP27P1-BPTFP1-KPNA2P3 →	+0.258	+0.129	<.001	<.001	3	4
OV	TGFBR2 →	+0.710	+0.101	<.001	.001	3	4
LSCC	C8orf33 →	-0.450	-0.246	<.001	.005	3	4
PDAC	MLANA →	+0.233	+0.140	.004	<.001	3	3
GBM	RHOD →	-1.101	-0.112	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903371 vs C21orf62-AS1 — GBM

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