Regulation of endoplasmic reticulum tubular network organization

Across TCGA cell cohorts, RNA activity of the Regulation of endoplasmic reticulum tubular network organization pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEBP1, CILK1, and GALNT3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HEBP1 grouped by Regulation of endoplasmic reticulum tubular network organization-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	HEBP1 →	-0.882	-2.018	<.001	<.001	3	4
SOFT_TISSUE	CILK1 →	-0.684	-1.493	.005	<.001	2	5
KIDNEY	GALNT3 →	-3.222	-1.703	.009	.008	3	3
KIDNEY	RECK →	-1.350	-2.007	.001	<.001	3	3
KIDNEY	AKT1 →	-0.979	-1.776	.009	.001	3	3
KIDNEY	FBXO41 →	-1.609	-1.273	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HEBP1 by Regulation of endoplasmic reticulum tubular network organization activity — UPPER_AERODIGESTIVE_TRACT

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