Regulation of endoplasmic reticulum tubular network organization

Across TCGA cell cohorts, RNA activity of the Regulation of endoplasmic reticulum tubular network organization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LNPK, ZNF528, and ELOC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endoplasmic reticulum tubular network organization activity versus LNPK in LUNG_SCLC (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LNPK →	+0.924	+1.385	.005	<.001	3	5
STOMACH	ZNF528 →	+2.337	+1.282	.009	.004	3	5
LIVER	ELOC →	+0.844	+1.572	.001	.004	3	4
LARGE_INTESTINE	MAML2 →	+0.935	+0.997	.009	.002	3	4
LUNG_NSCLC_LUAD	CENPL →	+0.802	+0.998	<.001	.002	3	4
PANCREAS	ADGRF3 →	+0.252	+0.993	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903371 vs LNPK — LUNG_SCLC

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