Protein localization to basolateral plasma membrane

Across TCGA patient cohorts, RNA activity of the Protein localization to basolateral plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SOWAHC_S213, GNL1, and PODXL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to basolateral plasma membrane activity versus SOWAHC_S213 in BRCA (Pearson r = -0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SOWAHC_S213 →	+0.464	+0.042	.004	.002	3	5
CCRCC	GNL1 →	+0.142	+0.068	<.001	<.001	3	5
CCRCC	PODXL →	+0.377	+0.055	.001	.003	3	5
CCRCC	GFPT2 →	-0.835	-0.080	<.001	<.001	3	4
PDAC	ACSF3 →	-0.209	-0.040	.004	<.001	3	4
UCEC	LMNA →	+0.501	+0.062	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903361 vs SOWAHC_S213 — BRCA

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