Negative regulation of bicellular tight junction assembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of bicellular tight junction assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ASH2L, ELF3, and EPB41L1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of bicellular tight junction assembly activity versus ASH2L in LSCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ASH2L →	+0.377	+0.067	.004	.008	3	5
COAD	ELF3 →	+0.280	+0.037	<.001	.003	3	4
COAD	EPB41L1 →	+0.496	+0.053	<.001	<.001	3	4
LSCC	POLB →	+0.518	+0.086	<.001	<.001	2	5
CCRCC	HSPA4_S415 →	-0.196	-0.042	.006	.003	3	4
LUAD	MTR →	+0.237	+0.062	.007	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903347 vs ASH2L — LSCC

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