Negative regulation of bicellular tight junction assembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of bicellular tight junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFAND2A-DT, PDHA1P1, and ANKRD22, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of bicellular tight junction assembly activity versus ZFAND2A-DT in LUAD (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ZFAND2A-DT →	+0.478	+0.201	.001	.004	3	4
CCRCC	PDHA1P1 →	-0.250	-0.316	.005	<.001	3	3
UCEC	ANKRD22 →	+0.912	+0.361	.001	.002	3	3
LUAD	HEMK1 →	+0.363	+0.187	.002	.001	3	3
LUAD	ATP13A4 →	+1.298	+0.153	.001	.003	3	3
LUAD	HLA-DRA →	+0.571	+0.249	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903347 vs ZFAND2A-DT — LUAD

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