Negative regulation of bicellular tight junction assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of bicellular tight junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYLK, NEU1, and IGFBP6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of bicellular tight junction assembly activity versus MYLK in BLOOD_Myeloma (Pearson r = 0.93).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MYLK →	+2.333	+0.262	.005	<.001	3	5
BLOOD_Leukemia	NEU1 →	-1.007	-0.251	<.001	<.001	3	5
BLOOD_Myeloma	IGFBP6 →	+1.866	+0.262	.002	<.001	3	4
BLOOD_Leukemia	NEXN →	+1.400	+0.174	.003	.005	3	4
BLOOD_Lymphoma	GLIPR1 →	+2.135	+0.315	<.001	.006	3	4
SKIN	IER3 →	+2.824	+0.417	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903347 vs MYLK — BLOOD_Myeloma

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