Positive regulation of protein modification by small protein conjugation or removal

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein modification by small protein conjugation or removal pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCNP, ZFP1, and CNBP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein modification by small protein conjugation or removal activity versus PCNP in PANCREAS (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PCNP →	+0.870	+0.351	<.001	<.001	3	5
LARGE_INTESTINE	ZFP1 →	+1.184	+0.176	<.001	.001	3	5
LUNG_SCLC	CNBP →	+0.605	+0.293	<.001	<.001	3	5
LARGE_INTESTINE	RABL3 →	+0.559	+0.190	<.001	<.001	3	5
BONE	CIRBP →	+1.268	+0.415	.001	.002	3	5
PANCREAS	CDK17 →	+1.162	+0.262	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903322 vs PCNP — PANCREAS

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