Regulation of protein maturation

Across TCGA cell cohorts, RNA activity of the Regulation of protein maturation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F8A3, ME3, and FLNB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, F8A3 grouped by Regulation of protein maturation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	F8A3 →	-1.620	-1.110	.004	.002	3	5
CNS	ME3 →	-1.291	-0.698	.002	.003	3	5
SOFT_TISSUE	FLNB →	-1.976	-1.103	.002	.003	3	4
LIVER	ITGA5 →	-3.101	-1.624	<.001	<.001	3	4
LIVER	ZNF853 →	+1.038	+2.037	.009	<.001	3	4
BLOOD_Leukemia	WDR55 →	-0.542	-1.246	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

F8A3 by Regulation of protein maturation activity — SKIN

Explore this box plot interactively →