Regulation of regulated secretory pathway

Across TCGA patient cohorts, RNA activity of the Regulation of regulated secretory pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGSF6, CEACAM3, and PELATON, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of regulated secretory pathway activity versus IGSF6 in LSCC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IGSF6 →	+0.648	+0.328	<.001	<.001	3	6
LSCC	CEACAM3 →	+0.802	+0.305	<.001	<.001	3	6
LSCC	PELATON →	+0.745	+0.267	<.001	<.001	3	6
LSCC	CCRL2 →	+0.877	+0.340	<.001	<.001	3	6
PDAC	CCR1 →	+0.645	+0.122	<.001	.007	3	6
HNSC	PIK3R5 →	+0.751	+0.209	.003	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903305 vs IGSF6 — LSCC

Explore this scatter interactively →