Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NOL3, PLEKHA5_S885, and WDTC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway activity versus NOL3 in BRCA (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NOL3 →	+0.535	+0.054	.001	<.001	3	8
BRCA	PLEKHA5_S885 →	+0.778	+0.070	.005	.003	3	5
LUAD	WDTC1 →	+0.181	+0.044	.001	.003	3	5
LUAD	PIK3CB →	+0.204	+0.053	.001	.001	3	5
GBM	TDP1 →	-0.254	-0.044	<.001	<.001	3	4
GBM	SUPT16H →	-0.534	-0.076	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903298 vs NOL3 — BRCA

Explore this scatter interactively →