Positive regulation of tumor necrosis factor-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of tumor necrosis factor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRB2, CSF2RB, and LILRA1, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of tumor necrosis factor-mediated signaling pathway activity versus LILRB2 in LAML (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	LILRB2 →	+1.612	+0.045	.001	<.001	3	33
TGCT	CSF2RB →	+1.417	+0.068	<.001	<.001	3	32
LAML	LILRA1 →	+1.534	+0.055	<.001	<.001	3	32
SCLC	PIK3CG →	+1.236	+0.146	<.001	<.001	3	32
SARC	IL10RA →	+1.502	+0.056	<.001	<.001	3	32
BLCA	CASP1 →	+1.903	+0.084	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903265 vs LILRB2 — LAML

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