Positive regulation of tumor necrosis factor-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of tumor necrosis factor-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XAF1, GBP2, and GBP4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of tumor necrosis factor-mediated signaling pathway activity versus XAF1 in GBM (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	XAF1 →	+0.736	+0.077	.001	.003	3	8
UCEC	GBP2 →	+0.596	+0.086	<.001	.001	3	8
UCEC	GBP4 →	+0.810	+0.103	<.001	<.001	3	8
LUAD	SAMD9 →	+0.448	+0.068	<.001	<.001	3	7
LSCC	SAMD9L →	+0.514	+0.079	<.001	<.001	3	7
GBM	SEPTIN1 →	+0.851	+0.070	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903265 vs XAF1 — GBM

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