Positive regulation of tumor necrosis factor-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of tumor necrosis factor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPCP2, CXCL1, and PPIB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of tumor necrosis factor-mediated signaling pathway activity versus HNRNPCP2 in PDAC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HNRNPCP2 →	+0.508	+0.222	<.001	<.001	3	4
LSCC	CXCL1 →	+1.168	+0.187	<.001	<.001	3	4
PDAC	PPIB →	+0.257	+0.161	<.001	<.001	3	4
COAD	LUCAT1 →	+0.497	+0.192	<.001	.001	3	4
UCEC	MYL6P5 →	+0.847	+0.160	<.001	.002	3	4
UCEC	ARHGAP19 →	-0.427	-0.151	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903265 vs HNRNPCP2 — PDAC

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