Positive regulation of tumor necrosis factor-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of tumor necrosis factor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZDHHC8, UROD, and APOBEC3H, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZDHHC8 grouped by Positive regulation of tumor necrosis factor-mediated signaling pathway-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZDHHC8 →	+1.072	+1.137	<.001	<.001	3	5
SOFT_TISSUE	UROD →	+0.868	+1.434	.006	.008	3	5
STOMACH	APOBEC3H →	-0.508	-1.090	.001	.002	3	5
KIDNEY	FDXR →	-1.624	-1.644	.003	<.001	3	5
OESOPHAGUS	KAT2A →	+0.773	+1.006	<.001	.002	3	4
OESOPHAGUS	ZNF606 →	+1.768	+1.187	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZDHHC8 by Positive regulation of tumor necrosis factor-mediated signaling pathway activity — LUNG_SCLC

Explore this box plot interactively →