Multi-ciliated epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Multi-ciliated epithelial cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSP90AA1, RFC2, and RFC5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multi-ciliated epithelial cell differentiation activity versus HSP90AA1 in COAD (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HSP90AA1 →	+0.292	+0.029	<.001	.001	3	6
GBM	RFC2 →	+0.482	+0.128	<.001	<.001	3	6
GBM	RFC5 →	+0.540	+0.119	<.001	<.001	3	6
LSCC	ADPRH →	-0.290	-0.054	<.001	.001	3	6
BRCA	PPM1F →	-0.188	-0.046	.002	.001	3	6
GBM	TLN1 →	-0.309	-0.078	.002	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903251 vs HSP90AA1 — COAD

Explore this scatter interactively →