Multi-ciliated epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Multi-ciliated epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS33A, CRTC3, and AHSA2P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multi-ciliated epithelial cell differentiation activity versus VPS33A in LSCC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VPS33A →	+0.244	+0.121	.002	.009	3	3
LSCC	CRTC3 →	+0.426	+0.132	<.001	.004	3	3
LSCC	AHSA2P →	+0.359	+0.108	<.001	.001	3	3
LSCC	ADAT1 →	+0.264	+0.128	.001	.006	3	3
LUAD	MEF2D →	-0.306	-0.207	.001	.006	3	3
COAD	MPLKIP →	+0.355	+0.195	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903251 vs VPS33A — LSCC

Explore this scatter interactively →