Multi-ciliated epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Multi-ciliated epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN2C, TMEM35B, and CDHR5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDKN2C grouped by Multi-ciliated epithelial cell differentiation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CDKN2C →	+6.500	+1.370	<.001	.001	3	4
LUNG_SCLC	TMEM35B →	-1.590	-0.985	.002	.002	3	4
LIVER	CDHR5 →	+1.804	+1.151	.006	.006	3	4
URINARY_TRACT	TRIB3 →	-2.752	-1.914	.009	<.001	3	3
OVARY	CTIF →	+0.988	+1.157	.008	.002	3	3
OVARY	ASB18 →	+0.083	+0.868	.008	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDKN2C by Multi-ciliated epithelial cell differentiation activity — BLOOD_Myeloma

Explore this box plot interactively →