Regulation of leukocyte tethering or rolling

Across TCGA patient cohorts, RNA activity of the Regulation of leukocyte tethering or rolling pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO2_S363, RCSD1, and CNRIP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of leukocyte tethering or rolling activity versus SYNPO2_S363 in UCEC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYNPO2_S363 →	+1.197	+0.060	.001	<.001	3	10
BRCA	RCSD1 →	+0.491	+0.054	<.001	<.001	3	9
OV	CNRIP1 →	+0.763	+0.068	<.001	<.001	3	9
OV	COL15A1 →	+0.648	+0.068	<.001	<.001	3	9
GBM	FES →	+0.491	+0.065	<.001	<.001	3	9
HNSC	FNBP1 →	+0.549	+0.081	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903236 vs SYNPO2_S363 — UCEC

Explore this scatter interactively →