Regulation of protein localization to plasma membrane

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to plasma membrane pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH3B1, HCCS, and OR2K2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALDH3B1 grouped by Regulation of protein localization to plasma membrane-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ALDH3B1 →	-0.348	-0.073	.002	.006	3	5
CNS	HCCS →	-0.313	-0.072	<.001	.002	3	5
LUNG_NSCLC_LUAD	OR2K2 →	+0.188	+0.056	<.001	<.001	3	5
LUNG_NSCLC_LUAD	APOC2 →	-0.126	-0.050	.001	<.001	3	5
CNS	PPP1R12A →	+0.394	+0.063	.001	.004	3	5
LIVER	BCL11A →	-0.184	-0.068	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALDH3B1 by Regulation of protein localization to plasma membrane activity — BLOOD_Lymphoma

Explore this box plot interactively →