Regulation of protein lipidation

Across TCGA patient cohorts, RNA activity of the Regulation of protein lipidation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS10P14, DNAJC14, and TMEM256P2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein lipidation activity versus RPS10P14 in CCRCC (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPS10P14 →	-0.553	-0.627	.002	.001	2	4
LUAD	DNAJC14 →	+0.198	+0.436	.008	.002	3	3
LUAD	TMEM256P2 →	-0.548	-0.416	.008	.002	3	3
LUAD	RPL15P18 →	-0.371	-0.393	.004	.009	3	3
CCRCC	PRDX6 →	+0.296	+0.518	.003	.006	3	3
CCRCC	LRRC37A12P →	-0.092	-0.486	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903059 vs RPS10P14 — CCRCC

Explore this scatter interactively →