DnaJ heat shock protein family (Hsp40) member C14Genealiases: DNAJ · DRIP78 · HDJ3 · LIP6
Q-omics provides the consensus-scored DNAJC14 profile across patient tissues and cancer cell-line models. DNAJC14 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in CESC. Among the 18 cancer types available for tumor–normal comparison, DNAJC14 is differentially expressed in 14, with the highest sampling consensus in HNSC. Additionally, DNAJC14 RNA expression shows 20,149 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight CESC, HNSC, and ACC as cancer lineages where DNAJC14 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for DNAJC14 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes DNAJC14 survival associations across molecular data types. DNAJC14 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (8) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible DNAJC14 RNA expression–survival associations across cancer types. High DNAJC14 expression shows unfavorable associations in CESC, MESO and PAAD, but favorable associations in KIRC, UCS and HNSC. The CESC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify CESC as the clearest survival context for DNAJC14 RNA expression.
This table summarizes DNAJC14 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 6. The strongest signals are observed in HNSC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for DNAJC14. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. DNAJC14 shows lower tumor expression in THCA and higher tumor expression in HNSC, BLCA, LIHC, BRCA and CHOL. The HNSC box plot shows higher DNAJC14 RNA expression in tumor versus normal tissue (log2 FC = +0.814, t-test p < 0.001).
This table shows molecular features associated with DNAJC14 in patient tissues and cancer cell lines. In patient samples, DNAJC14 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, DNAJC14 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in STOMACH, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and UPPER_AERODIGESTIVE_TRACT.
