Protein localization to membrane raft

Across TCGA patient cohorts, RNA activity of the Protein localization to membrane raft pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are YME1L1, SVIL_S547, and CLPX, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to membrane raft activity versus YME1L1 in LUAD (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	YME1L1 →	-0.322	-0.073	<.001	<.001	3	9
UCEC	SVIL_S547 →	+1.123	+0.106	.002	<.001	3	8
UCEC	CLPX →	-0.273	-0.103	<.001	.001	3	8
OV	CYGB →	+0.556	+0.063	.009	.003	3	8
GBM	DAB2 →	+0.668	+0.092	<.001	<.001	3	8
LUAD	RFC4 →	-0.338	-0.076	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903044 vs YME1L1 — LUAD

Explore this scatter interactively →