Positive regulation of opsonization

Across TCGA patient cohorts, RNA activity of the Positive regulation of opsonization pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPTBN1_S1388, CAMSAP1, and RASIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of opsonization activity versus SPTBN1_S1388 in PDAC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SPTBN1_S1388 →	+0.678	+0.084	<.001	<.001	3	5
GBM	CAMSAP1 →	-0.131	-0.079	.003	.008	3	5
CCRCC	RASIP1 →	+0.413	+0.079	<.001	<.001	3	5
BRCA	HAAO →	+0.477	+0.047	.004	.001	3	5
LSCC	SNX1_S280 →	+0.418	+0.057	<.001	<.001	3	4
CCRCC	SHANK3 →	+0.391	+0.088	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903028 vs SPTBN1_S1388 — PDAC

Explore this scatter interactively →