Positive regulation of glycoprotein metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of glycoprotein metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADD3, ATP9A, and ACADS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADD3 grouped by Positive regulation of glycoprotein metabolic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ADD3 →	+1.723	+1.350	.004	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	ATP9A →	+2.102	+1.805	.001	<.001	3	5
LARGE_INTESTINE	ACADS →	+0.884	+0.474	.001	.002	3	5
STOMACH	DENND6A →	+0.898	+1.726	.007	.001	3	4
PANCREAS	KDM4C →	+0.622	+1.431	.006	<.001	3	4
LARGE_INTESTINE	GPC4 →	+1.471	+0.439	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADD3 by Positive regulation of glycoprotein metabolic process activity — PANCREAS

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