Regulation of glycoprotein metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of glycoprotein metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADPRS, BECN1, and CTNNB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADPRS grouped by Regulation of glycoprotein metabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ADPRS →	-0.298	-1.193	.005	.004	3	4
CNS	BECN1 →	-0.307	-1.004	.009	.003	2	5
LARGE_INTESTINE	CTNNB1 →	-1.104	-0.394	<.001	<.001	3	4
PANCREAS	WWTR1 →	+0.292	+0.947	.002	.005	2	5
PANCREAS	CSF3 →	-0.421	-1.233	.003	.008	3	4
CNS	NECAB2 →	-0.218	-1.456	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADPRS by Regulation of glycoprotein metabolic process activity — LUNG_SCLC

Explore this box plot interactively →