Regulation of glycoprotein metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of glycoprotein metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DENND4C, PLPP6, and TMPRSS6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DENND4C grouped by Regulation of glycoprotein metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DENND4C →	+1.332	+0.437	<.001	<.001	3	5
LARGE_INTESTINE	PLPP6 →	+0.799	+0.286	<.001	.005	3	5
BREAST	TMPRSS6 →	+0.499	+0.562	.004	.006	3	4
LUNG_NSCLC_LUAD	ANGPTL4 →	-1.687	-0.630	<.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	ATP6V1F →	+0.808	+1.230	.005	.006	3	4
SOFT_TISSUE	APOA2 →	+0.942	+1.163	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DENND4C by Regulation of glycoprotein metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →