Regulation of glycoprotein metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of glycoprotein metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F11R, OVOL1, and ITGB6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glycoprotein metabolic process activity versus F11R in PANCREAS (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	F11R →	+2.226	+0.312	<.001	<.001	3	7
PANCREAS	OVOL1 →	+2.063	+0.325	<.001	<.001	3	5
PANCREAS	ITGB6 →	+3.247	+0.276	<.001	.001	3	5
PANCREAS	WDR35 →	-1.077	-0.284	.001	<.001	3	5
PANCREAS	RPS27A →	-0.624	-0.313	.002	<.001	3	5
PANCREAS	TNFSF13 →	+2.065	+0.327	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903018 vs F11R — PANCREAS

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