Regulation of glycoprotein metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of glycoprotein metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS12, CTNNB1, and RAB1B, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glycoprotein metabolic process activity versus RPS12 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RPS12 →	-1.868	-0.517	<.001	.008	3	10
BONE	CTNNB1 →	+1.275	+1.005	.005	.002	3	9
OESOPHAGUS	RAB1B →	+1.058	+0.333	.003	<.001	2	10
BONE	RPS5 →	-0.566	-1.281	<.001	<.001	3	8
BONE	AHSA1 →	-0.530	-1.097	.001	<.001	3	8
PANCREAS	RPL24 →	-1.171	-0.268	<.001	.007	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903018 vs RPS12 — UPPER_AERODIGESTIVE_TRACT

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