Negative regulation of amyloid precursor protein catabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of amyloid precursor protein catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPON1, ATXN2L, and MAOB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of amyloid precursor protein catabolic process activity versus SPON1 in UCEC (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPON1 →	+0.829	+0.080	<.001	<.001	3	6
GBM	ATXN2L →	-0.116	-0.047	.001	.002	3	6
COAD	MAOB →	+0.423	+0.037	.003	.005	2	6
GBM	PUM1 →	-0.170	-0.067	.004	.003	3	5
BRCA	TK2 →	+0.264	+0.040	.003	.003	3	5
GBM	SMARCC1 →	-0.315	-0.062	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902992 vs SPON1 — UCEC

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