Negative regulation of amyloid precursor protein catabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of amyloid precursor protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R16B, PRKCB, and ANKRD44, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of amyloid precursor protein catabolic process activity versus PPP1R16B in GBM (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PPP1R16B →	+1.899	+0.387	<.001	<.001	3	7
GBM	PRKCB →	+1.018	+0.222	<.001	<.001	3	7
UCEC	ANKRD44 →	+0.592	+0.169	<.001	<.001	3	7
LSCC	MEF2C →	+0.537	+0.312	<.001	.002	3	7
LSCC	FAM78A →	+0.383	+0.276	.001	.007	3	7
GBM	HTR2A →	+0.978	+0.226	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902992 vs PPP1R16B — GBM

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