Negative regulation of amyloid precursor protein catabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of amyloid precursor protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL7R, HOXC11, and PAAF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IL7R grouped by Negative regulation of amyloid precursor protein catabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	IL7R →	-2.360	-1.051	<.001	.004	2	5
PANCREAS	HOXC11 →	+1.587	+0.767	<.001	.005	3	4
STOMACH	PAAF1 →	-0.828	-1.482	.001	<.001	3	4
LIVER	ARPC1B →	-0.893	-1.565	.007	.005	3	4
BLOOD_Lymphoma	SAT1 →	+2.030	+1.793	.006	<.001	3	4
LUNG_SCLC	CDK6 →	-2.145	-1.364	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IL7R by Negative regulation of amyloid precursor protein catabolic process activity — OESOPHAGUS

Explore this box plot interactively →