Negative regulation of amyloid precursor protein catabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of amyloid precursor protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLU, C12orf45, and TMUB2, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of amyloid precursor protein catabolic process activity versus CLU in OVARY (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CLU →	+3.544	+0.155	<.001	<.001	3	14
OESOPHAGUS	C12orf45 →	-0.769	-0.090	.005	.006	3	12
LARGE_INTESTINE	TMUB2 →	+0.537	+0.117	.007	.003	3	11
URINARY_TRACT	VPS9D1 →	+1.377	+0.158	.001	<.001	3	10
OESOPHAGUS	P2RX6 →	+1.205	+0.116	.001	<.001	3	10
BLOOD_Leukemia	PLD3 →	+1.217	+0.078	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902992 vs CLU — OVARY

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