Negative regulation of amyloid precursor protein catabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of amyloid precursor protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPTN, PAIP1, and ANO1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of amyloid precursor protein catabolic process activity versus NPTN in BLOOD_Myeloma (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	NPTN →	+1.127	+0.394	<.001	.004	3	6
BONE	PAIP1 →	+0.826	+0.336	<.001	.008	3	6
BREAST	ANO1 →	+2.582	+0.203	.001	.004	3	5
BONE	RPUSD4 →	-0.975	-0.507	.006	.002	3	5
LARGE_INTESTINE	RPS9 →	-0.702	-0.250	<.001	.002	3	5
OVARY	IMPDH1 →	-1.296	-0.232	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902992 vs NPTN — BLOOD_Myeloma

Explore this scatter interactively →