Regulation of amyloid precursor protein catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of amyloid precursor protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKAG2, ANKRD28, and GPD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKAG2 grouped by Regulation of amyloid precursor protein catabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PRKAG2 →	-2.225	-1.519	.001	<.001	3	4
LUNG_NSCLC_LUSC	ANKRD28 →	-1.209	-0.967	.003	.009	3	4
SOFT_TISSUE	GPD2 →	+1.933	+1.037	.002	.001	3	4
LUNG_NSCLC_LUAD	GLIPR1 →	-2.152	-0.791	<.001	<.001	3	4
BLOOD_Myeloma	RIN1 →	-0.728	-1.457	.006	.001	3	4
LUNG_SCLC	DCTN3 →	+0.941	+0.900	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKAG2 by Regulation of amyloid precursor protein catabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →