Mitotic DNA replication

Across TCGA patient cohorts, RNA activity of the Mitotic DNA replication pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC2, RFC4, and RPL12_S38, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic DNA replication activity versus RFC2 in OV (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RFC2 →	+0.449	+0.062	<.001	<.001	3	10
OV	RFC4 →	+0.543	+0.053	<.001	.002	3	10
LUAD	RPL12_S38 →	+1.347	+0.137	<.001	<.001	3	10
GBM	RRM1 →	+0.460	+0.087	<.001	<.001	3	10
LUAD	RRM2 →	+1.001	+0.137	<.001	<.001	3	10
LUAD	ATAD2_S342 →	+1.712	+0.133	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902969 vs RFC2 — OV

Explore this scatter interactively →