Positive regulation of protein localization to early endosome

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein localization to early endosome pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR89A, SPECC1L, and CCNB1IP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to early endosome activity versus GPR89A in LSCC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GPR89A →	-0.367	-0.136	<.001	.005	3	5
LSCC	SPECC1L →	-0.304	-0.127	<.001	<.001	3	4
LSCC	CCNB1IP1 →	-0.538	-0.142	<.001	<.001	3	4
LSCC	NUP155 →	-0.682	-0.173	<.001	<.001	3	4
LSCC	RPS17 →	-0.501	-0.204	<.001	<.001	3	4
LSCC	PARP9 →	+0.752	+0.161	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902966 vs GPR89A — LSCC

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