Regulation of dendritic spine maintenance

Across TCGA patient cohorts, RNA activity of the Regulation of dendritic spine maintenance pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NHP2P1, RNU6-853P, and MAL, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendritic spine maintenance activity versus NHP2P1 in LSCC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NHP2P1 →	-0.341	-0.267	<.001	.008	3	3
LUAD	RNU6-853P →	-0.543	-0.157	<.001	.003	3	3
BRCA	MAL →	+0.530	+0.181	<.001	<.001	3	3
CCRCC	C9orf116 →	-0.428	-0.497	.005	.001	3	3
UCEC	MYADML2 →	+0.119	+0.260	.003	.001	3	3
HNSC	FAM102A →	-0.542	-0.277	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902950 vs NHP2P1 — LSCC

Explore this scatter interactively →