Protein localization to early endosome

Across TCGA patient cohorts, RNA activity of the Protein localization to early endosome pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDC4, NUTM2HP, and MADD-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to early endosome activity versus SDC4 in GBM (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SDC4 →	+0.863	+0.811	<.001	<.001	3	4
LUAD	NUTM2HP →	+0.146	+0.230	<.001	<.001	3	4
GBM	MADD-AS1 →	-0.313	-0.616	.006	.003	3	4
PDAC	LRRC37A13P →	-0.176	-0.372	.007	.005	3	3
CCRCC	C1orf100 →	-0.271	-0.216	.001	.002	3	3
CCRCC	RPL36AP15 →	-0.658	-0.216	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902946 vs SDC4 — GBM

Explore this scatter interactively →